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Glutathione Intervention in Diabetes Mellitus
| CO-PI(s): | Walter Williams |
University of Louisville
Atherosclerosis (AS) is the leading cause of death in patients with diabetes mellitus (DM). Several lines of evidence suggest that oxidative stress is involved in the development of DM and AS. A possible correction is to intervene by altering glutathione (GSH) status, the most abundant cellular antioxidant. This is based on a combined GSH and cysteine (Cys) deficiency occurs in DM. Our hypothesis is that GSH-Cys status plays an important role in the pathophysiology of DM and its related condition, obesity. To test this, diabetic mouse models, db/db and ob/ob genetic strains will be studied.. The plan is (1) to determine their free and bound GSH-Cys and lipid peroxidation status, (2) to evaluate various thiazolidines and GSH monoethyl ester for their GSH-Cys enhancing capacity, and (3) to assess the effectiveness of these enhancers on the pathophysiology of diabetes. The expected results should lead to new insights into an old problem and provide a potential treatment for diabetes and its cardiovascular complications.
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