Category Biosciences
Abstract Despite advances in screening and early detection, liver tumors still have a dismal overall 5-year survival rate of 16%. The incidence of liver tumors in the US has tripled in the past two decades and has become the fastest rising cause of cancer related death in the United States. Partial hepatectomy and liver transplant are the primary curative treatments liver tumors. However, many patients are not eligible for these curative therapies due to the severity of underlying liver disease, or poor overall health status. Local therapies have been shown to improve survival rates and can serve as effective bridging therapy to transplant in some patient populations. Percutaneous chemoablation via direct injection of ethanol (PEI) or acetic acid has historically shown to be relatively efficacious and safe in tumors less than 3cm in diameter. However, this seemingly straightforward approach is often eschewed in favor of thermal ablation techniques that have shown to produce better overall survival rates. The limited efficacy of PEI has been attributed to uneven infusate distribution after injection caused by ethanol’s inability to diffuse through fibrous septa and capsules within tumor tissue, thus often requiring multiple injections. Thus, the limited distribution of ethanol or anticancer drugs may account for impaired efficacy, and by default, improved distribution of therapeutic agents in liver tumors has the potential to improve liver tumor therapy. However, a proven intratumoral injection device technology has yet to be developed that ensures optimal delivery of these agents. Porous delivery devices have the potential to offer an improved, minimally invasive delivery of therapeutic agents to liver and other solid tumors. The proposed work plan will advance commercial development of a Porous Needle with milestones including FDA registration, inventory build and customer commitments to use in human studies.
Amount Awarded $150,000
Keywords drug delivery, cancer, liver tumors, medical device, needles
Point of Contact Jim Stice
[email protected]
Twin Star Medical, Inc.
Location Lexington
Fayette County